Photo of Michael T. Jaklitsch,  MD

Michael T. Jaklitsch, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6988
Fax: (617) 730-2898

Michael T. Jaklitsch, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Surgery, Harvard Medical School
  • Thoracic Surgeon, Thoracic Surgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The elderly patient is particularly susceptible to suffer morbidity after major thoracic surgical procedures. Previous work from Brigham & Women's Hospital has shown that this subgroup has a thirteen-fold higher incidence of postoperative dementia after non-cardiac thoracic surgery. The full recovery time from major thoracic surgical procedures is poorly understood in this subgroup. This is an extremely pertinent issue. Current data are unavailable to advise the eighty-five-year-old patient with a presumed early stage lung cancer as to which treatment option may be expected to maximize the future quality of life. New instruments of measurement are required to address these issues. I am currently developing clinical measurements of the elderly patient's functional status, motivation for surgery, understanding of surgery, and quality of life. I plan to test these measurements in our outpatient elderly population over the next year.

Publications from Harvard Catalyst Profiles

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  • Lapidot M, Mazzola E, Freyaldenhoven S, De León LE, Jaklitsch MT, Bueno R. Postoperative empyema after pleurectomy decortication for malignant pleural mesothelioma. Ann Thorac Surg 2021. PubMed
  • Dezube AR, Dolan DP, Mazzola E, Kucukak S, De Leon LE, Bueno R, Marshall MB, Jaklitsch MT, Rochefort MM. Risk factors for prolonged air leak and need for intervention following lung resection. Interact Cardiovasc Thorac Surg 2021. PubMed
  • Dezube AR, Kucukak S, De Leon LE, Wiener D, Rochefort MM, Jaklitsch MT. Internal Staging Discordance in National Cancer Databases for Non-Small-Cell Lung Cancer. Ann Thorac Surg 2021. PubMed
  • Dezube AR, Mazzola E, Deeb A, Wiener D, Marshall MB, Rochefort M, Jaklitsch MT. Mandatory Nodal Evaluation During Resection of Clinical T1a Non-Small-Cell Lung Cancers. Ann Thorac Surg 2021. PubMed
  • Cooper L, Dezube AR, De León LE, Kucukak S, Mazzola E, Dumontier C, Mamon H, Enzinger P, Jaklitsch MT, Frain LN, Wee JO. Outcomes of trimodality CROSS regimen in older adults with locally advanced esophageal cancer. Eur J Surg Oncol 2021. PubMed
  • Jacobson FL, Dezube AR, Bravo-Iñiguez C, Kucukak S, Bay CP, Wee JO, Coppolino AA, Jaklitsch MT, Ducko CT. Preserving NLST mortality benefits and acceptable morbidity for lung cancer surgery in a community hospital. J Surg Oncol 2021. PubMed
  • Dezube AR, Kucukak S, De León LE, Kostopanagiotou K, Jaklitsch MT, Wee JO. Risk of chyle leak after robotic versus video-assisted thoracoscopic esophagectomy. Surg Endosc 2021. PubMed
  • Bravo-Iñiguez CE, He Z, Dezube AR, Mazzola E, Yelamanchili N, Zhao L, Bueno R, Swanson SJ, White A, Wiener DC, Jaklitsch MT, Wee JO. Impact of radial margins after esophagectomy for esophageal cancer. Eur J Surg Oncol 2021. PubMed
  • White A, Kucukak S, Lee DN, Mazzola E, Dolan D, Bueno R, Jaklitsch MT, Swanson SJ. Chemotherapy and surgical resection for N1 positive non-small cell lung cancer: Better than expected outcomes. Semin Thorac Cardiovasc Surg 2021. PubMed
  • White AA, Lee DN, Mazzola E, Kucukak S, Polhemus E, Jaklitsch MT, Mentzer SJ, Wee JO, Bueno R, Swanson SJ. Adjuvant therapy following induction therapy and surgery improves survival in N2-positive non-small cell lung cancer. J Surg Oncol 2021; 123:579-586. PubMed
  • Dolan DP, White A, Mazzola E, Lee DN, Gill R, Kucukak S, Bueno R, Jaklitsch MT, Mentzer SJ, Swanson SJ. Outcomes of superior segmentectomy versus lower lobectomy for superior segment Stage I non-small-cell lung cancer are equivalent: An analysis of 196 patients at a single, high volume institution. J Surg Oncol 2021; 123:570-578. PubMed
  • Lapidot M, Gill RR, Mazzola E, Freyaldenhoven S, Swanson SJ, Jaklitsch MT, Sugarbaker DJ, Bueno R. Pleurectomy Decortication in the Treatment of Malignant Pleural Mesothelioma: Encouraging Results and Novel Prognostic Implications Based on Experience in 355 Consecutive Patients. Ann Surg 2020. PubMed
  • Dezube AR, Mazzola E, Bravo-Iñiguez CE, De León LE, Rochefort MM, Bueno R, Wiener DC, Jaklitsch MT, . Analysis of Lymph Node Sampling Minimums in Early Stage Non-Small-Cell Lung Cancer. Semin Thorac Cardiovasc Surg 2020. PubMed
  • Rodriguez M, Dezube AR, Bravo-Iniguez CE, Fox S, De León LE, Tarascio J, Freyaldenhoven S, Mentzer SJ, Swanson SJ, Bueno R, Rochefort MM, Marshall MB, Jaklitsch MT. Impact of Neoadjuvant Chemoradiation On Adverse Events Following Bronchial Sleeve Resection. Ann Thorac Surg 2020. PubMed
  • De León LE, Rochefort MM, Bravo-Iñiguez CE, Fox SW, Tarascio JN, Cardin K, DuMontier C, Frain LN, Jaklitsch MT. Opportunities for quality improvement in the morbidity pattern of older adults undergoing pulmonary lobectomy for cancer. 2020. PubMed
  • Dezube AR, Cooper L, Jaklitsch MT. Prehabilitation of the Thoracic Surgery Patient. Thorac Surg Clin 2020; 30:249-258. PubMed
  • Jaklitsch MT, Jacobson FL. The future of lung cancer screening with low-dose computed tomography. J Thorac Cardiovasc Surg 2020; 160:289-294. PubMed
  • Gill RR, Barlow J, Jaklitsch MT, Schmidlin EJ, Hartigan PM, Bueno R. Image-guided video-assisted thoracoscopic resection (iVATS): Translation to clinical practice-real-world experience. J Surg Oncol 2020. PubMed
  • White A, Kucukak S, Lee DN, Bueno R, Jaklitsch M, Mentzer S, Sugarbaker D, Wee J, Swanson SJ. Completion pneumonectomy is safe and effective in select patients with recurrent non-small cell lung cancer. J Thorac Dis 2020; 12:217-222. PubMed
  • Dezube AR, Bravo-Iñiguez CE, Yelamanchili N, De León LE, Tarascio J, Jaklitsch MT, Wee JO. Risk factors for delirium after esophagectomy. J Surg Oncol 2020; 121:645-653. PubMed
  • Dezube AR, Jaklitsch MT. New evidence supporting lung cancer screening with low dose CT & surgical implications. Eur J Surg Oncol 2020. PubMed
  • Dezube AR, Jaklitsch MT. Minimizing residual occult nodal metastasis in NSCLC: recent advances, current status and controversies. Expert Rev Anticancer Ther 2020; 20:117-130. PubMed
  • De León LE, Bravo-Iñiguez CE, Fox S, Tarascio J, Freyaldenhoven S, Lapidot M, Jaklitsch MT, Bueno R. Routine surveillance for diagnosis of venous thromboembolism after pleurectomy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg 2020. PubMed
  • Montroni I, Rostoft S, Spinelli A, Van Leeuwen BL, Ercolani G, Saur NM, Jaklitsch MT, Somasundar PS, de Liguori Carino N, Ghignone F, Foca F, Zingaretti C, Audisio RA, Ugolini G, . GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery: early analysis on 977 patients. 2019. PubMed
  • Bravo-Iñiguez CE, Fox SW, De Leon LE, Tarascio JN, Jaklitsch MT, Jacobson FL. Cumulative nonsmoking risk factors increase the probability of developing lung cancer. J Thorac Cardiovasc Surg 2019. PubMed
  • Cooley ME, Blonquist TM, Hong F, Nayak MM, Crouter SE, Hayman LL, Jaklitsch MT, Emmons KM, Bueno R. The effect of a lifestyle risk reduction intervention on lifestyle adherence and health-related quality of life in nonsmall cell lung cancer survivors: Feasibility study outcomes. 2019; 28:920-923. PubMed
  • Burt BM, Richards WG, Lee HS, Bartel S, Dasilva MC, Gill RR, Jaklitsch MT, Johnson BE, Swanson SJ, Bueno R, Sugarbaker DJ. A Phase I Trial of Surgical Resection and Intraoperative Hyperthermic Cisplatin and Gemcitabine for Pleural Mesothelioma. J Thorac Oncol 2018. PubMed
  • Wiener DC, Bravo-Iñiguez CE, Trien-Vihn Ho V, Qian X, Jaklitsch MT. Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung. Ann Thorac Surg 2018; 105:e145-e147. PubMed
  • Wiener DC, Kaplan TB, Bravo-Iñiguez CE, Miller J, Berkowitz AL, Jaklitsch MT. Paraneoplastic Neuromyelitis Optica Spectrum Disorder as Presentation of Esophageal Adenocarcinoma. Ann Thorac Surg 2018; 105:e133-e135. PubMed
  • Randhawa S, Moore RF, DiSesa V, Kaiser L, Ma GX, Jaklitsch MT, Erkmen CP. Role of Thoracic Surgeons in Lung Cancer Screening: Opportune Time for Involvement. J Thorac Oncol 2018; 13:298-300. PubMed
  • Jacobson FL, Jaklitsch MT. Computed Tomography Scanning for Early Detection of Lung Cancer. Annu Rev Med 2018; 69:235-245. PubMed
  • Digesu CS, Hachey KJ, Gilmore DM, Khullar OV, Tsukada H, Whang B, Chirieac LR, Padera RF, Jaklitsch MT, Colson YL. Long-term outcomes after near-infrared sentinel lymph node mapping in non-small cell lung cancer. J Thorac Cardiovasc Surg 2017. PubMed
  • Ducko CT, Bravo-Iñiguez CE, Jaklitsch MT, Jacobson FL, Wee JO. Starfish model: Recruiting academic surgeons to provide thoracic surgery in the community setting. J Surg Oncol 2017; 115:782-783. PubMed
  • Bahcall M, Sim T, Paweletz CP, Patel JD, Alden RS, Kuang Y, Sacher AG, Kim ND, Lydon C, Awad MM, Jaklitsch MT, Sholl LM, Jänne PA, Oxnard GR. Acquired MET D1228V Mutation and Resistance to MET Inhibition in Lung Cancer. 2016. PubMed
  • Cleary JM, Mamon HJ, Szymonifka J, Bueno R, Choi N, Donahue DM, Fidias PM, Gaissert HA, Jaklitsch MT, Kulke MH, Lynch TP, Mentzer SJ, Meyerhardt JA, Swanson RS, Wain J, Fuchs CS, Enzinger PC. Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer. BMC Cancer 2016; 16:468. PubMed
  • Wee JO, Bravo-Iñiguez CE, Jaklitsch MT. Early Experience of Robot-Assisted Esophagectomy With Circular End-to-End Stapled Anastomosis. Ann Thorac Surg 2016; 102:253-9. PubMed
  • Gill RR, Jaklitsch MT, Jacobson FL. Controversies in Lung Cancer Screening. J Am Coll Radiol 2016; 13:R2-7. PubMed
  • Bravo Iñiguez CE, Armstrong KW, Cooper Z, Weissman JS, Ducko CT, Wee JO, Martinez MP, Bueno R, Jaklitsch MT, Wiener DC. Thirty-Day Mortality After Lobectomy in Elderly Patients Eligible for Lung Cancer Screening. Ann Thorac Surg 2015. PubMed
  • Mody GN, Bravo Iñiguez C, Armstrong K, Perez Martinez M, Ferrone M, Bono C, Chi JH, Wee JO, Lebenthal A, Swanson SJ, Colson YL, Bueno R, Jaklitsch MT. Early Surgical Outcomes of En Bloc Resection Requiring Vertebrectomy for Malignancy Invading the Thoracic Spine. Ann Thorac Surg 2015. PubMed
  • Gill RR, Zheng Y, Barlow JS, Jayender J, Girard EE, Hartigan PM, Chirieac LR, Belle-King CJ, Murray K, Sears C, Wee JO, Jaklitsch MT, Colson YL, Bueno R. Image-guided video assisted thoracoscopic surgery (iVATS) - phase I-II clinical trial. J Surg Oncol 2015; 112:18-25. PubMed
  • Jaklitsch MT. "How am I doing? Just ask me!" The usefulness of patient self-reported quality of life in thoracic surgery. J Thorac Cardiovasc Surg 2015; 149:663-4. PubMed
  • Mazzone P, Powell CA, Arenberg D, Bach P, Detterbeck F, Gould MK, Jaklitsch MT, Jett J, Naidich D, Vachani A, Wiener RS, Silvestri G. Components necessary for high-quality lung cancer screening: American College of Chest Physicians and American Thoracic Society Policy Statement. Chest 2015; 147:295-303. PubMed
  • Pallis AG, Gridelli C, Wedding U, Faivre-Finn C, Veronesi G, Jaklitsch M, Luciani A, O'Brien M. Management of elderly patients with NSCLC; updated expert's opinion paper: EORTC Elderly Task Force, Lung Cancer Group and International Society for Geriatric Oncology. Ann Oncol 2014; 25:1270-83. PubMed
  • Mohiuddin K, Haneuse S, Sofer T, Gill R, Jaklitsch MT, Colson YL, Wee J, Bueno R, Mentzer SJ, Sugarbaker DJ, Swanson SJ. Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (≤2 cm) non-small cell lung cancer. J Thorac Cardiovasc Surg 2014; 147:1169-75; discussion 1175-7. PubMed
  • Jaklitsch MT. Meeting the challenges of centrally located non-small-cell lung cancer. Oncology (Huntingt) 2014; 28:221, 227-8. PubMed
  • Gill RR, Jaklitsch MT, Jacobson FL. Controversies in lung cancer screening. J Am Coll Radiol 2013; 10:931-6. PubMed
  • Jacobson FL, Jaklitsch MT. Low-dose CT screening for lung cancer: the time is now. J Surg Oncol 2013; 108:265-9. PubMed
  • Gilmore DM, Khullar OV, Jaklitsch MT, Chirieac LR, Frangioni JV, Colson YL. Identification of metastatic nodal disease in a phase 1 dose-escalation trial of intraoperative sentinel lymph node mapping in non-small cell lung cancer using near-infrared imaging. J Thorac Cardiovasc Surg 2013; 146:562-70; discussion 569-70. PubMed
  • Jaklitsch MT, Gu L, Demmy T, Harpole DH, D'Amico TA, McKenna RJ, Krasna MJ, Kohman LJ, Swanson SJ, DeCamp MM, Wang X, Barry S, Sugarbaker DJ, . Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol 39803. J Thorac Cardiovasc Surg 2013; 146:9-16. PubMed
  • Oxman DA, Issa NC, Marty FM, Patel A, Panizales CZ, Johnson NN, Licona JH, McKenna SS, Frendl G, Mentzer SJ, Jaklitsch MT, Bueno R, Colson Y, Swanson SJ, Sugarbaker DJ, Baden LR. Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg 2013. PubMed
  • Billmeier SE, Ayanian JZ, He Y, Jaklitsch MT, Rogers SO. Predictors of nursing home admission, severe functional impairment, or death one year after surgery for non-small cell lung cancer. Ann Surg 2013; 257:555-63. PubMed
  • Lee MS, Mamon HJ, Hong TS, Choi NC, Fidias PM, Kwak EL, Meyerhardt JA, Ryan DP, Bueno R, Donahue DM, Jaklitsch MT, Lanuti M, Rattner DW, Fuchs CS, Enzinger PC. Preoperative cetuximab, irinotecan, cisplatin, and radiation therapy for patients with locally advanced esophageal cancer. Oncologist 2013; 18:281-7. PubMed
  • Jaklitsch MT, Jacobson FL. Reply to the editor. J Thorac Cardiovasc Surg 2013; 145:308. PubMed
  • Jacobson FL, Jaklitsch MT. Lung cancer screening trials: the United States and beyond. J Thorac Cardiovasc Surg 2012; 144:S3-6. PubMed
  • Jaklitsch MT, Jacobson FL, Austin JH, Field JK, Jett JR, Keshavjee S, MacMahon H, Mulshine JL, Munden RF, Salgia R, Strauss GM, Swanson SJ, Travis WD, Sugarbaker DJ. The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups. J Thorac Cardiovasc Surg 2012; 144:33-8. PubMed
  • Jacobson FL, Austin JH, Field JK, Jett JR, Keshavjee S, MacMahon H, Mulshine JL, Munden RF, Salgia R, Strauss GM, Sugarbaker DJ, Swanson SJ, Travis WD, Jaklitsch MT. Development of The American Association for Thoracic Surgery guidelines for low-dose computed tomography scans to screen for lung cancer in North America: recommendations of The American Association for Thoracic Surgery Task Force for Lung Cancer Screenin J Thorac Cardiovasc Surg 2012; 144:25-32. PubMed
  • Sugarbaker DJ, Wolf AS, Chirieac LR, Godleski JJ, Tilleman TR, Jaklitsch MT, Bueno R, Richards WG. Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy. 2011. PubMed
  • Richards WG, Godleski JJ, Yeap BY, Corson JM, Chirieac LR, Zellos L, Mujoomdar A, Jaklitsch MT, Bueno R, Sugarbaker DJ. Proposed adjustments to pathologic staging of epithelial malignant pleural mesothelioma based on analysis of 354 cases. Cancer 2010; 116:1510-7. PubMed
  • Goguen LA, Norris CM, Jaklitsch MT, Sullivan CA, Posner MR, Haddad RI, Tishler RB, Burke E, Annino DJ. Combined antegrade and retrograde esophageal dilation for head and neck cancer-related complete esophageal stenosis. Laryngoscope 2010; 120:261-6. PubMed
  • Cooley ME,Sarna L,Kotlerman J,Lukanich JM,Jaklitsch M,Green SB,Bueno R. Smoking cessation is challenging even for patients recovering from lung cancer surgery with curative intent. Lung Cancer 2009; 66:218-25. PubMed
  • Tilleman TR, Richards WG, Zellos L, Johnson BE, Jaklitsch MT, Mueller J, Yeap BY, Mujoomdar AA, Ducko CT, Bueno R, Sugarbaker DJ. Extrapleural pneumonectomy followed by intracavitary intraoperative hyperthermic cisplatin with pharmacologic cytoprotection for treatment of malignant pleural mesothelioma: a phase II prospective study. J Thorac Cardiovasc Surg 2009; 138:405-11. PubMed
  • Khalpey Z, Camp P, Jaklitsch MT. Left circumflex to bronchial artery fistula. Ann Thorac Surg 2009; 88:303. PubMed
  • Paul S,Escareno CE,Clancy K,Jaklitsch MT,Bueno R,Lautz DB. Gastrointestinal complications after lung transplantation. J Heart Lung Transplant 2009; 28:475-9. PubMed
  • Zellos L,Richards WG,Capalbo L,Jaklitsch MT,Chirieac LR,Johnson BE,Bueno R,Sugarbaker DJ. A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesothelioma. J Thorac Cardiovasc Surg 2009; 137:453-8. PubMed
  • Neragi-Miandoab S, Linden PA, Ducko CT, Bueno R, Richards WG, Sugarbaker DJ, Jaklitsch MT. VATS pericardiotomy for patients with known malignancy and pericardial effusion: survival and prognosis of positive cytology and metastatic involvement of the pericardium: a case control study. Int J Surg 2008; 6:110-4. PubMed
  • Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, Korman A, Lautz D, Russell S, Jaklitsch MT, Ramaiya N, Chen TC, Neuberg D, Allison JP, Mihm MC, Dranoff G. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A 2008; 105:3005-10. PubMed
  • Linden PA, Wee JO, Jaklitsch MT, Colson YL. Extending indications for radiofrequency ablation of lung tumors through an intraoperative approach. Ann Thorac Surg 2008; 85:420-3. PubMed
  • Chang MY, Mentzer SJ, Colson YL, Linden PA, Jaklitsch MT, Lipsitz SR, Sugarbaker DJ. Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg 2007; 134:850-6. PubMed
  • Silletti JP, Gordon GJ, Bueno R, Jaklitsch M, Loughlin KR. Prostate biopsy: past, present, and future. Urology 2007; 69:413-6. PubMed
  • Linden PA, Bueno R, Mentzer SJ, Zellos L, Lebenthal A, Colson YL, Sugarbaker DJ, Jaklitsch MT. Modified T-tube repair of delayed esophageal perforation results in a low mortality rate similar to that seen with acute perforations. Ann Thorac Surg 2007; 83:1129-33. PubMed
  • Linden PA, Yeap BY, Chang MY, Henderson WG, Jaklitsch MT, Khuri S, Sugarbaker DJ, Bueno R. Morbidity of lung resection after prior lobectomy: results from the Veterans Affairs National Surgical Quality Improvement Program. Ann Thorac Surg 2007; 83:425-31; discussion 432. PubMed
  • Jaklitsch MT, Herndon JE, DeCamp MM, Richards WG, Kumar P, Krasna MJ, Green MR, Sugarbaker DJ. Nodal downstaging predicts survival following induction chemotherapy for stage IIIA (N2) non-small cell lung cancer in CALGB protocol #8935. J Surg Oncol 2006; 94:599-606. PubMed
  • Richards WG, Zellos L, Bueno R, Jaklitsch MT, Jänne PA, Chirieac LR, Yeap BY, Dekkers RJ, Hartigan PM, Capalbo L, Sugarbaker DJ. Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma. J Clin Oncol 2006; 24:1561-7. PubMed
  • Mukhopadhyay NK, Weisberg E, Gilchrist D, Bueno R, Sugarbaker DJ, Jaklitsch MT. Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. Ann Thorac Surg 2006; 81:1034-42. PubMed
  • Linden PA, Gilbert RJ, Yeap BY, Boyle K, Deykin A, Jaklitsch MT, Sugarbaker DJ, Bueno R. Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation. J Thorac Cardiovasc Surg 2006; 131:438-46. PubMed
  • VanSonnenberg E, Shankar S, Morrison PR, Nair RT, Silverman SG, Jaklitsch MT, Liu F, Cheung L, Tuncali K, Skarin AT, Sugarbaker DJ. Radiofrequency ablation of thoracic lesions: part 2, initial clinical experience--technical and multidisciplinary considerations in 30 patients. AJR Am J Roentgenol 2005; 184:381-90. PubMed
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