Research Abstract
Our lab examines the mechanism by which inflammatory immune responses contribute to the development and progression of colorectal cancer.
Jason S. Gold
Brigham And Women's Hospital
Brigham And Women's Hospital
Phone: (857) 203-5764
Fax: (857) 203-5738
Jason S. Gold
Brigham And Women's Hospital
EDUCATIONAL TITLES
DF/HCC PROGRAM AFFILIATION
Publications from Harvard Catalyst Profiles
- Del Valle JP, Fillmore NR, Molina G, Fairweather M, Wang J, Clancy TE, Ashley SW, Urman RD, Whang EE, Gold JS. Socioeconomic Disparities in Pancreas Cancer Resection and Survival in the Veterans Health Administration. Ann Surg Oncol 2022; 29:3194-3202. PubMed
- Nandi B, Del Valle JP, Samur MK, Gibbons AJ, Prabhala RH, Munshi NC, Gold JS. CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways. 2021; 12:2323-2337. PubMed
- Pastrana Del Valle J, Mahvi DA, Fairweather M, Wang J, Clancy TE, Ashley SW, Urman RD, Whang EE, Gold JS. Associations of gender, race, and ethnicity with disparities in short-term adverse outcomes after pancreatic resection for cancer. J Surg Oncol 2021. PubMed
- Frank MH, Wilson BJ, Gold JS, Frank NY. Clinical Implications of colorectal cancer stem cells in the age of single-cell OMICs and targeted therapies. Gastroenterology 2021. PubMed
- Huang Q, Read M, Gold JS, Zou X. Unraveling the Identity of Gastric Cardiac Cancer. J Dig Dis 2020. PubMed
- Pastrana Del Valle J, Mahvi DA, Fairweather M, Wang J, Clancy TE, Ashley SW, Urman RD, Whang EE, Gold JS. The improvement in post-operative mortality following pancreaticoduodenectomy between 2006 and 2016 is associated with an improvement in the ability to rescue patients after major morbidity, not in the rate of major morbidity. 2020. PubMed
- Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P. Systemic Therapy for Melanoma: ASCO Guideline. J Clin Oncol 2020. PubMed
- Saadat LV, Mahvi DA, Jolissaint JS, Urman RD, Gold JS, Whang EE. Discharge destination following rectal cancer resection: an analysis of preoperative and intraoperative factors. Int J Colorectal Dis 2019. PubMed
- Gold JS. Linking Disparities to Outcomes in Pancreatic Cancer: Inching Toward Answers. JAMA Surg 2019. PubMed
- Saadat LV, Mahvi DA, Jolissaint JS, Gabriel RA, Urman R, Gold JS, Whang EE. Twenty-Three-Hour-Stay Colectomy Without Increased Readmissions: An Analysis of 1905 Cases from the National Surgical Quality Improvement Program. World J Surg 2019. PubMed
- Mahvi DA, Pak LM, Bose SK, Urman RD, Gold JS, Whang EE. Fast-Track Pancreaticoduodenectomy: Factors Associated with Early Discharge. World J Surg 2019; 43:1332-1341. PubMed
- Mahvi DA, Pak LM, Urman RD, Gold JS, Whang EE. Discharge destination following pancreaticoduodenectomy: A NSQIP analysis of predictive factors and post-discharge outcomes. Am J Surg 2018. PubMed
- Huang Q, Cheng Y, Chen L, Mingzhan D, Wang Y, Xu G, Shi J, Fan X, Zhou X, Zhang Y, Guo L, Liu T, Zhou D, Mashimo H, Gold JS, Zou X, . Low risk of lymph node metastasis in 495 early gastric cardiac carcinomas: a multicenter clinicopathologic study of 2101 radical gastrectomies for early gastric carcinoma. Mod Pathol 2018. PubMed
- Guo Q, Grimmig T, Gonzalez G, Giobbie-Hurder A, Berg G, Carr N, Wilson BJ, Banerjee P, Ma J, Gold JS, Nandi B, Huang Q, Waaga-Gasser AM, Lian CG, Murphy GF, Frank MH, Gasser M, Frank NY. ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer. J Biol Chem 2018. PubMed
- Lyu HG, Sharma G, Brovman EY, Ejiofor J, Urman RD, Gold JS, Whang EE. Unplanned reoperation after hepatectomy: an analysis of risk factors and outcomes. 2018. PubMed
- Lyu HG, Sharma G, Brovman E, Ejiofor J, Repaka A, Urman RD, Gold JS, Whang EE. Risk Factors of Reoperation After Pancreatic Resection. Dig Dis Sci 2017. PubMed
- Shapiro M, Nandi B, Gonzalez G, Prabhala RH, Mashimo H, Huang Q, Frank NY, Munshi NC, Gold JS. Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis. Oncoimmunology 2017; 6:e1261776. PubMed
- Izar B, Joyce CE, Goff S, Cho NL, Shah PM, Sharma G, Li J, Ibrahim N, Gold J, Hodi FS, Garraway LA, Novina CD, Bertagnolli MM, Yoon CH. Bidirectional cross talk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation. Pigment Cell Melanoma Res 2016. PubMed
- Nandi B, Shapiro M, Samur MK, Pai C, Frank NY, Yoon C, Prabhala RH, Munshi NC, Gold JS. Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages. Oncoimmunology 2016; 5:e1189052. PubMed
- Fang C, Shi J, Sun Q, Gold JS, Xu G, Liu W, Zou X, Huang Q. Risk Factors of Lymph Node Metastasis in Early Gastric Carcinomas Diagnosed with WHO Criteria in 379 Chinese Patients. J Dig Dis 2016. PubMed
- Shapiro M, Chen Q, Huang Q, Boosalis VA, Yoon CH, Saund MS, Whang EE, Gold JS. Associations of Socioeconomic Variables With Resection, Stage, and Survival in Patients With Early-Stage Pancreatic Cancer. JAMA Surg 2015. PubMed
- Shapiro M, Nandi B, Pai C, Samur MK, Pelluru D, Fulciniti M, Prabhala RH, Munshi NC, Gold JS. Deficiency of IL-17A, but not the prototypical Th17 transcription factor RORγt, decreases murine spontaneous intestinal tumorigenesis. Cancer Immunol Immunother 2015. PubMed
- Huang Q, Shi J, Sun Q, Gold JS, Chen J, Wu H, Yu H, Zhang Y, Mashimo H, Yu C, Manasco T, Guan W, Lauwers GY. Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population. Pathology 2015. PubMed
- Shapiro M, Rashid NU, Whang EE, Boosalis VA, Huang Q, Yoon C, Saund MS, Gold JS. Trends and predictors of resection of the primary tumor for patients with stage IV colorectal cancer. J Surg Oncol 2015; 111:911-6. PubMed
- Fang C, Huang Q, Lu L, Shi J, Sun Q, Xu GF, Gold J, Mashimo H, Zou XP. Risk factors of early proximal gastric carcinoma in Chinese diagnosed using WHO criteria. J Dig Dis 2015; 16:327-36. PubMed
- Shapiro M, Rashid NU, Huang Q, Galper SL, Boosalis VA, Whang EE, Gold JS. Radiation therapy for unresectable pancreatic adenocarcinoma: population-based trends in utilization and survival rates in the United States. JAMA Surg 2015; 150:274-7. PubMed
- Huang Q, Fang C, Shi J, Sun Q, Wu H, Gold JS, Weber HC, Guan W, Zhang Y, Yu C, Zou X, Mashimo H. Differences in Clinicopathology of Early Gastric Carcinoma between Proximal and Distal Location in 438 Chinese Patients. Sci Rep 2015; 5:13439. PubMed
- Shi J, Sun Q, Xu BY, Yu HP, Zhang YF, Zou XP, Huang L, Gold JS, Mashimo H, Yu CG, Huang Q. Changing trends in the proportions of small (≤ 2 cm) proximal and non-proximal gastric carcinomas treated at a high-volume tertiary medical center in China. J Dig Dis 2014; 15:359-66. PubMed
- Nandi B, Pai C, Huang Q, Prabhala RH, Munshi NC, Gold JS. CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS ONE 2014; 9:e97566. PubMed
- Gold JS, Al Natour RH, Saund MS, Yoon C, Sharma AM, Huang Q, Boosalis VA, Whang EE. Population-based outcome of stage IA-IIA resected gastric adenocarcinoma: who should get adjuvant treatment? Ann Surg Oncol 2013. PubMed
- Zhang YF, Shi J, Yu HP, Feng AN, Fan XS, Lauwers GY, Mashimo H, Gold JS, Chen G, Huang Q. Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus. World J Gastroenterol 2012; 18:3602-9. PubMed
- Huang Q, Gold JS, Shi J, Fan X, Wu H, Feng A, Zhou Q. Pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus. Hum Pathol 2012. PubMed
- Al Natour RH, Saund MS, Sanchez VM, Whang EE, Sharma AM, Huang Q, Boosalis VA, Gold JS. Tumor size and depth predict rate of lymph node metastasis in colon carcinoids and can be used to select patients for endoscopic resection. J Gastrointest Surg 2012. PubMed
- Saund MS, Al Natour RH, Sharma AM, Huang Q, Boosalis VA, Gold JS. Tumor size and depth predict rate of lymph node metastasis and utilization of lymph node sampling in surgically managed gastric carcinoids. Ann Surg Oncol 2011. PubMed
- Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res 2011. PubMed
- Abramson MA, Pandharipande P, Ruan D, Gold JS, Whang EE. Radical resection for T1b gallbladder cancer: a decision analysis. 2009; 11:656-63. PubMed
- Gold JS, Gönen M, Gutiérrez A, Broto JM, GarcÃa-del-Muro X, Smyrk TC, Maki RG, Singer S, Brennan MF, Antonescu CR, Donohue JH, DeMatteo RP. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. Lancet Oncol 2009; 10:1045-52. PubMed
- Dematteo RP,Gold JS,Saran L,Gonen M,Liau KH,Maki RG,Singer S,Besmer P,Brennan MF,Antonescu CR. Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer 2008; 112:608-15. PubMed
- Gold JS,Are C,Kornprat P,Jarnagin WR,Gonen M,Fong Y,DeMatteo RP,Blumgart LH,D'Angelica M. Increased use of parenchymal-sparing surgery for bilateral liver metastases from colorectal cancer is associated with improved mortality without change in oncologic outcome: trends in treatment over time in 440 patients. Ann Surg 2008; 247:109-17. PubMed
- Gold JS,Tang LH,Gonen M,Coit DG,Brennan MF,Allen PJ. Utility of a prognostic nomogram designed for gastric cancer in predicting outcome of patients with R0 resected duodenal adenocarcinoma. Ann Surg Oncol 2007; 14:3159-67. PubMed
- Gold JS,Jaques DP,Busam KJ,Brady MS,Coit DG. Yield and predictors of radiologic studies for identifying distant metastases in melanoma patients with a positive sentinel lymph node biopsy. Ann Surg Oncol 2007; 14:2133-40. PubMed
- Gold JS,Dematteo RP. Neoadjuvant therapy for gastrointestinal stromal tumor (GIST): racing against resistance. Ann Surg Oncol 2007; 14:1247-8. PubMed
- Gold JS,Jaques DP,Bentrem DJ,Shah MA,Tang LH,Brennan MF,Coit DG. Outcome of patients with known metastatic gastric cancer undergoing resection with therapeutic intent. Ann Surg Oncol 2007; 14:365-72. PubMed
- Gold JS,van der Zwan SM,Gonen M,Maki RG,Singer S,Brennan MF,Antonescu CR,De Matteo RP. Outcome of metastatic GIST in the era before tyrosine kinase inhibitors. Ann Surg Oncol 2007; 14:134-42. PubMed
- Ferrone CR,Perales MA,Goldberg SM,Somberg CJ,Hirschhorn-Cymerman D,Gregor PD,Turk MJ,Ramirez-Montagut T,Gold JS,Houghton AN,Wolchok JD. Adjuvanticity of plasmid DNA encoding cytokines fused to immunoglobulin Fc domains. Clin Cancer Res 2006; 12:5511-9. PubMed
- Gold JS,Dematteo RP. Combined surgical and molecular therapy: the gastrointestinal stromal tumor model. Ann Surg 2006; 244:176-84. PubMed
- Gold JS,Donovan PI,Udelsman R. Partial median sternotomy: an attractive approach to mediastinal parathyroid disease. World J Surg 2006; 30:1234-9. PubMed
- Engelhorn ME,Guevara-Patino JA,Noffz G,Hooper AT,Lou O,Gold JS,Kappel BJ,Houghton AN. Autoimmunity and tumor immunity induced by immune responses to mutations in self. Nat Med 2006; 12:198-206. PubMed
JONATHAN A. FLETCHER, MD Brigham And Women's HospitalCANCER GENETICS AND EPIGENETICS, GASTROINTESTINAL MALIGNANCIES, SARCOMA
GEORGE D. DEMETRI, MD Dana-Farber Cancer InstituteDEVELOPMENTAL THERAPEUTICS, GASTROINTESTINAL MALIGNANCIES, SARCOMA
ANNICK D. VAN DEN ABBEELE, MD, FACR, FICIS Dana-Farber Cancer InstituteCANCER IMAGING, LUNG CANCER, LYMPHOMA AND MYELOMA, SARCOMA