Photo of Jorge E. Chavarro,

Jorge E. Chavarro

Brigham And Women's Hospital

Brigham And Women's Hospital


jchavarr@hsph.harvard.edu

Photo of Jorge E. Chavarro,

Brigham And Women's Hospital


jchavarr@hsph.harvard.edu

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Jorge E. Chavarro

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Professor, Epidemiology, Harvard T.H. Chan School Of Public Health
  • Professor, Nutrition, Harvard T.H. Chan School Of Public Health
  • Associate Epidemiologist, Medicine, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on investigating the role of diet and the interaction between dietary and genetic factors in the pathogenesis of diseases affecting reproductive and hormone sensitive organs, particularly malignancies of reproductive organs. This broad interest is currently focused in two areas. First, I am investigating the role of fatty acids and their metabolism in the development and progression of prostate cancer. Using data from ongoing cohort studies, I study the relationships of dietary fatty acid intakes and biomarkers of fatty acid intake and their metabolism, including de novo lipogenesis, with prostate cancer risk and survival. Also, because prostate cancer treatment often has adverse cardiovascular and metabolic consequences, I am investigating the role of modifiable lifestyle factors on non-cancer mortally, particularly cardiovascular disease, among men with prostate cancer.

In addition to my prostate cancer work, I am currently investigating how different

dietary and lifestyle factors are related to male and female fertility and infertility treatment outcomes with the goal of identifying strategies for fertility preservation in cancer survivors and in the general population.

Publications from Harvard Catalyst Profiles

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  • Farland LV, Wang S, Rich-Edwards JW, Gaskins AJ, Chavarro JE, Wang YX, Tamimi RM, Missmer SA. History of infertility and risk of breast cancer: a prospective cohort study. Breast Cancer Res Treat 2023. PubMed
  • Wang S, Gaskins AJ, Farland LV, Zhang D, Birmann BM, Rich-Edwards JW, Wang YX, Tamimi RM, Missmer SA, Chavarro JE. A prospective cohort study of infertility and cancer incidence. Fertil Steril 2023. PubMed
  • Ardisson Korat AV, Chiu YH, Bertrand KA, Zhang S, Epstein MM, Rosner BA, Chiuve S, Campos H, Giovannucci EL, Chavarro JE, Birmann BM. A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma. Leuk Lymphoma 2022. PubMed
  • Wang S, Wang YX, Sandoval-Insausti H, Farland LV, Shifren JL, Zhang D, Manson JE, Birmann BM, Willett WC, Giovannucci EL, Missmer SA, Chavarro JE. Menstrual cycle characteristics and incident cancer: a prospective cohort study. Hum Reprod 2022; 37:341-351. PubMed
  • Cote DJ, Bever AM, Chiu YH, Sandoval-Insausti H, Smith-Warner SA, Chavarro JE, Stampfer MJ. Pesticide residue intake from fruit and vegetable consumption and risk of glioma. Am J Epidemiol 2022. PubMed
  • Ding M, Fitzmaurice GM, Arvizu M, Willett WC, Manson JE, Rexrode KM, Hu FB, Chavarro JE. Associations between patterns of modifiable risk factors in mid-life to late life and longevity: 36 year prospective cohort study. BMJ Med 2022; 1:e000098. PubMed
  • Sandoval-Insausti H, Chiu YH, Wang YX, Hart JE, Bhupathiraju SN, Mínguez-Alarcón L, Ding M, Willett WC, Laden F, Chavarro JE. Intake of fruits and vegetables according to pesticide residue status in relation to all-cause and disease-specific mortality: Results from three prospective cohort studies. Environ Int 2022; 159:107024. PubMed
  • Sandoval-Insausti H, Chiu YH, Lee DH, Wang S, Hart JE, Mínguez-Alarcón L, Laden F, Ardisson Korat AV, Birmann B, Heather Eliassen A, Willett WC, Chavarro JE. Intake of fruits and vegetables by pesticide residue status in relation to cancer risk. Environ Int 2021; 156:106744. PubMed
  • Sakaki JR, Li J, Gao S, Ha K, Tamimi RM, Chavarro JE, Chen MH, Sun Q, Hart JE, Chun OK. Associations between fruit juice and milk consumption and change in BMI in a large prospective cohort of U.S. adolescents and preadolescents. Pediatr Obes 2021. PubMed
  • Nguyen LH, Drew DA, Joshi AD, Guo CG, Ma W, Mehta RS, Sikavi DR, Lo CH, Kwon S, Song M, Mucci LA, Stampfer MJ, Willett WC, Eliassen AH, Hart JE, Chavarro JE, Rich-Edwards JW, Davies R, Capdevila J, Lee KA, Lochlainn MN, Varsavsky T, Graham MS, Sudre CH, Cardoso MJ, Wolf J, Ourselin S, Steves CJ, Spector TD, Chan AT. Risk of COVID-19 among frontline healthcare workers and the general community: a prospective cohort study. medRxiv 2020. PubMed
  • Solazzo AL, Agénor M, Austin SB, Chavarro JE, Charlton BM. Sexual Orientation Differences in Cervical Cancer Prevention among a Cohort of U.S. Women. Womens Health Issues 2020. PubMed
  • Fore R, Hart JE, Choirat C, Thompson JW, Lynch K, Laden F, Chavarro JE, James P. Embedding Mobile Health Technology into the Nurses' Health Study 3 to Study Behavioral Risk Factors for Cancer. Cancer Epidemiol Biomarkers Prev 2020; 29:736-743. PubMed
  • Ardisson Korat AV, Chiu YH, Bertrand KA, Zhang S, Epstein MM, Rosner BA, Chiuve S, Campos H, Giovannucci EL, Chavarro JE, Birmann BM. Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case-control study. Am J Clin Nutr 2020; 112:1576-1583. PubMed
  • Labbé DP, Zadra G, Yang M, Reyes JM, Lin CY, Cacciatore S, Ebot EM, Creech AL, Giunchi F, Fiorentino M, Elfandy H, Syamala S, Karoly ED, Alshalalfa M, Erho N, Ross A, Schaeffer EM, Gibb EA, Takhar M, Den RB, Lehrer J, Karnes RJ, Freedland SJ, Davicioni E, Spratt DE, Ellis L, Jaffe JD, DʼAmico AV, Kantoff PW, Bradner JE, Mucci LA, Chavarro JE, Loda M, Brown M. High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program. Nat Commun 2019; 10:4358. PubMed
  • Lee DH, Yang M, Keum N, Giovannucci EL, Sun Q, Chavarro JE. Mushroom consumption and risk of total and site-specific cancer in two large US prospective cohorts. Cancer Prev Res (Phila Pa) 2019. PubMed
  • Ding M, Li J, Qi L, Ellervik C, Zhang X, Manson JE, Stampfer M, Chavarro JE, Rexrode KM, Kraft P, Chasman D, Willett WC, Hu FB. Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies. BMJ 2019; 367:l6204. PubMed
  • Hemler EC, Chavarro JE, Hu FB. Organic Foods for Cancer Prevention-Worth the Investment? JAMA Intern Med 2018; 178:1606-1607. PubMed
  • Chiu YH, Bertrand KA, Zhang S, Laden F, Epstein MM, Rosner BA, Chiuve S, Campos H, Giovannucci EL, Chavarro JE, Birmann BM. A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma. Int. J. Cancer 2018. PubMed
  • Kornides ML, Rimm EB, Chavarro JE, Gillman MW, Rosner B, Field AE. Seasonal Variations in Meeting Physical Activity Recommendations and Development of Overweight during Adolescence. Child Obes 2017. PubMed
  • Tabung FK, Smith-Warner SA, Chavarro JE, Fung TT, Hu FB, Willett WC, Giovannucci EL. An Empirical Dietary Inflammatory Pattern Score Enhances Prediction of Circulating Inflammatory Biomarkers in Adults. J Nutr 2017. PubMed
  • Tabung FK, Fung TT, Chavarro JE, Smith-Warner SA, Willett WC, Giovannucci EL. Associations between adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and biomarkers of inflammation, hormonal, and insulin response. Int. J. Cancer 2017; 140:764-776. PubMed
  • Tabung FK, Wang W, Fung TT, Hu FB, Smith-Warner SA, Chavarro JE, Fuchs CS, Willett WC, Giovannucci EL. Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. Br J Nutr 2016. PubMed
  • Yang M, Sesso HD, Colditz GA, Ma J, Stampfer MJ, Chavarro JE. Effect Modification by Time Since Blood Draw on the Association Between Circulating Fatty Acids and Prostate Cancer Risk. Journal of the National Cancer Institute 2016. PubMed
  • Yang M, Ayuningtyas A, Kenfield SA, Sesso HD, Campos H, Ma J, Stampfer MJ, Chavarro JE. Blood fatty acid patterns are associated with prostate cancer risk in a prospective nested case-control study. Cancer Causes Control 2016; 27:1153-61. PubMed
  • Tabung FK, Smith-Warner SA, Chavarro JE, Wu K, Fuchs CS, Hu FB, Chan AT, Willett WC, Giovannucci EL. Development and Validation of an Empirical Dietary Inflammatory Index. J Nutr 2016. PubMed
  • Yang M, Kenfield SA, Van Blarigan EL, Wilson KM, Batista JL, Sesso HD, Ma J, Stampfer MJ, Chavarro JE. Dairy intake after prostate cancer diagnosis in relation to disease-specific and total mortality. Int J Cancer 2015. PubMed
  • Huang T, Eliassen AH, Hankinson SE, Okereke OI, Kubzansky LD, Wang M, Poole EM, Chavarro JE, Tworoger SS. A prospective study of leisure-time physical activity and risk of incident epithelial ovarian cancer: Impact by menopausal status. Int J Cancer 2015. PubMed
  • Van Blarigan EL, Kenfield SA, Yang M, Sesso HD, Ma J, Stampfer MJ, Chan JM, Chavarro JE. Fat intake after prostate cancer diagnosis and mortality in the Physicians' Health Study. Cancer Causes Control 2015; 26:1117-26. PubMed
  • Yang M, Kenfield SA, Van Blarigan EL, Batista JL, Sesso HD, Ma J, Stampfer MJ, Chavarro JE. Dietary patterns after prostate cancer diagnosis in relation to disease-specific and total mortality. Cancer Prev Res (Phila Pa) 2015; 8:545-51. PubMed
  • Crowe FL, Appleby PN, Travis RC, Barnett M, Brasky TM, Bueno-de-Mesquita HB, Chajes V, Chavarro JE, Chirlaque MD, English DR, Gibson RA, Giles GG, Goodman GE, Henning SM, Kaaks R, King IB, Kolonel LN, Kristal AR, Neuhouser ML, Park SY, Severi G, Siddiq A, Stampfer MJ, Stattin P, Tangen CM, Tjønneland A, Trichopoulos D, Tumino R, Wilkens LR, Key TJ, Allen NE, . Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies. Journal of the National Cancer Institute 2014. PubMed
  • Tee MC, Cao Y, Warnock GL, Hu FB, Chavarro JE. Effect of bariatric surgery on oncologic outcomes: a systematic review and meta-analysis. Surg Endosc 2013; 27:4449-56. PubMed
  • Chavarro JE, Kenfield SA, Stampfer MJ, Loda M, Campos H, Sesso HD, Ma J. Blood levels of saturated and monounsaturated fatty acids as markers of de novo lipogenesis and risk of prostate cancer. Am J Epidemiol 2013; 178:1246-55. PubMed
  • Richman EL, Kenfield SA, Chavarro JE, Stampfer MJ, Giovannucci EL, Willett WC, Chan JM. Fat intake after diagnosis and risk of lethal prostate cancer and all-cause mortality. JAMA Intern Med 2013; 173:1318-26. PubMed
  • Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control 2013; 24:695-704. PubMed
  • Song Y, Chavarro JE, Cao Y, Qiu W, Mucci L, Sesso HD, Stampfer MJ, Giovannucci E, Pollak M, Liu S, Ma J. Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians. J Nutr 2013; 143:189-96. PubMed
  • Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival. J Clin Oncol 2010; 28:3958-64. PubMed
  • Chavarro JE,Stampfer MJ,Hall MN,Sesso HD,Ma J. A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. Am J Clin Nutr 2008; 88:1297-303. PubMed
  • Chavarro JE, Stampfer MJ, Campos H, Kurth T, Willett WC, Ma J. A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:95-101. PubMed
  • Chavarro JE, Stampfer MJ, Li H, Campos H, Kurth T, Ma J. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2007; 16:1364-70. PubMed
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DF/HCC members that share similar concepts* with Jorge E. Chavarro but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

Similar Members