Photo of Thomas Michel, MD, PhD

Thomas Michel, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7376


thomas_michel@harvard.edu

Photo of Thomas Michel, MD, PhD

Brigham And Women's Hospital
Phone: (617) 732-7376


thomas_michel@harvard.edu

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Thomas Michel, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Senior Physician, Medicine, Brigham And Women's Hospital
  • Consultant in Cardiology, Medicine, Dana-Farber Cancer Institute
  • Co-Director, Leder Human Biology and Translational Medicine Program, Biological and Biomedical Sciences, Harvard Medical School

Research Abstract

My lab uses biochemical and cell biological approaches to explore signal transduction pathways in the cells and tissues of the cardiovascular system. We are particularly focused on studying the roles of reactive oxygen species and of nitric oxide synthases in endothelial cells and cardiac myocytes in cardiovascular disease states, including heart failure, diabetes and atherosclerosis.

Publications from Harvard Catalyst Profiles

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  • Waldeck-Weiermair M, Yadav S, Spyropoulos F, Krüger C, Pandey AK, Michel T. Dissecting in vivo and in vitro redox responses using chemogenetics. Free Radic Biol Med 2021; 177:360-369. PubMed
  • Erdogan YC, Altun HY, Secilmis M, Ata BN, Sevimli G, Cokluk Z, Zaki AG, Sezen S, Akgul Caglar T, Sevgen İ, Steinhorn B, Ai H, Öztürk G, Belousov VV, Michel T, Eroglu E. Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting. Free Radic Biol Med 2021; 177:132-142. PubMed
  • Steinhorn B, Eroglu E, Michel T. Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology. Annu Rev Pharmacol Toxicol 2021. PubMed
  • Sorrentino A, Michel T. Redox à la carte: Novel chemogenetic models of heart failure. Br J Pharmacol 2020; 177:3162-3167. PubMed
  • Saeedi Saravi SS, Eroglu E, Waldeck-Weiermair M, Sorrentino A, Steinhorn B, Belousov V, Michel T. Differential endothelial signaling responses elicited by chemogenetic HO synthesis. Redox Biol 2020; 36:101605. PubMed
  • Eroglu E, Saravi SSS, Sorrentino A, Steinhorn B, Michel T. Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods. Proc Natl Acad Sci U S A 2019; 116:20210-20217. PubMed
  • Sorrentino A, Steinhorn B, Troncone L, Saravi SSS, Badole S, Eroglu E, Kijewski MF, Divakaran S, Di Carli M, Michel T. Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress. Am J Physiol Heart Circ Physiol 2019; 317:H617-H626. PubMed
  • Mishina NM, Bogdanova YA, Ermakova YG, Panova AS, Kotova DA, Bilan D, Steinhorn B, Arnér ESJ, Michel T, Belousov V. Which antioxidant system shapes intracellular H2O2 gradients? Antioxid Redox Signal 2019. PubMed
  • Steinhorn B, Sorrentino A, Badole S, Bogdanova Y, Belousov V, Michel T. Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. Nat Commun 2018; 9:4044. PubMed
  • Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med 2017; 113:16-25. PubMed
  • Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest 2016; 126:1323-36. PubMed
  • Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood 2016; 127:1468-80. PubMed
  • Steinhorn BS, Loscalzo J, Michel T. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med 2015; 373:277-80. PubMed
  • Tarrago L, Péterfi Z, Lee BC, Michel T, Gladyshev VN. Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors. Nat Chem Biol 2015. PubMed
  • Wang L, Hagemann TL, Kalwa H, Michel T, Messing A, Feany MB. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Nat Commun 2015; 6:8966. PubMed
  • Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem 2014. PubMed
  • Kalwa H, Sartoretto JL, Martinelli R, Romero N, Steinhorn BS, Tao M, Ozaki CK, Carman CV, Michel T. Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Natl Acad Sci U S A 2014; 111:3383-8. PubMed
  • Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metab 2014; 19:246-58. PubMed
  • Shiroto T, Romero N, Sugiyama T, Sartoretto JL, Kalwa H, Yan Z, Shimokawa H, Michel T. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS ONE 2014; 9:e87871. PubMed
  • Bretón-Romero R, Kalwa H, Lamas S, Michel T. Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Biochim Biophys Acta 2013; 1833:2586-95. PubMed
  • Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal 2013; 6:ra64. PubMed
  • Sartoretto JL, Kalwa H, Romero N, Michel T. In vivo imaging of nitric oxide and hydrogen peroxide in cardiac myocytes. Methods Enzymol 2013; 528:61-78. PubMed
  • Jin BY, Lin AJ, Golan DE, Michel T. MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability. Proc Natl Acad Sci U S A 2012; 109:14864-9. PubMed
  • Kalwa H, Sartoretto JL, Sartoretto SM, Michel T. Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium. J Biol Chem 2012; 287:29147-58. PubMed
  • Maron BA, Michel T. Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase. Circ J 2012; 76:2497-512. PubMed
  • Sartoretto JL, Kalwa H, Pluth MD, Lippard SJ, Michel T. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci U S A 2011; 108:15792-7. PubMed
  • Kalwa H, Michel T. The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem 2011; 286:2320-30. PubMed
  • Jin BY, Sartoretto JL, Gladyshev VN, Michel T. Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proc Natl Acad Sci U S A 2009; 106:17343-8. PubMed
  • Kou R, Sartoretto J, Michel T. Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. J Biol Chem 2009; 284:14734-43. PubMed
  • Sugiyama T, Levy BD, Michel T. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. J Biol Chem 2009; 284:12691-700. PubMed
  • Igarashi J, Michel T. Sphingosine-1-phosphate and modulation of vascular tone. Cardiovasc Res 2009; 82:212-20. PubMed
  • Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J. PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest 2009; 119:110-24. PubMed
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DF/HCC members that share similar concepts* with Thomas Michel, MD, PhD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

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