Research Abstract

My research program focuses on obesity and comorbidities, including malignancies. My basic research efforts utilize genomics-bioinformatics, animal physiology, and molecular biology studies to elucidate the role of new molecules important in energy homeostasis. I am a Professor of Medicine at Harvard Medical School in Boston, MA and I have a longstanding successful and highly recognized research program of clinical and translational metabolism at Beth Israel Deaconess Medical Center, where I am the founding director of the Section of Human Nutrition. I also serve as the chief of Endocrinology, Diabetes, and Metabolism at the Veterans Affairs Boston Healthcare System and I am adjunct professor at the Boston University School of Medicine in Boston, MA. As a practicing internist, endocrinologist, and dedicated educator, I have considered a pioneer and worldwide expert in obesity and metabolism. During my career, I have treated thousands of patients, mentored over 200 trainees and collaborators in my laboratory and beyond, and published over 1000 peer-reviewed articles that received 170,000 citations. I am also an educator who created and leads novel clinical training and education programs. My work has improved our understanding of the underlying pathophysiological mechanisms related to obesity, energy balance and metabolism, as well as related comorbidities including obesity related malignancies. My past and ongoing work has defined the role of the adipocyte-secreted hormone leptin in humans, and over the last years, the Mantzoros lab research has expanded to understand the physiology and the role of gastrointestinal hormones as well as the role of myokines and mitokines in obesity and obesity-related disorders and comorbidities. Our work has also resulted in patents for diagnostic and therapeutic applications, has directly contributed to the development of new pharmaceuticals by major pharmaceutical companies, and has contributed to the creation of new companies.