Photo of Cesar M. Castro,  MD, MMSc

Cesar M. Castro, MD, MMSc

Massachusetts General Hospital

Massachusetts General Hospital


cmcastro@partners.org

Cesar M. Castro, MD, MMSc

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School
  • Director, Gynecologic Oncology Program - MGH Cancer Center, Massachusetts General Hospital
  • Director, Cancer Program - MGH Center for Systems Biology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

DF/HCC ASSOCIATIONS

  • Member, Center Scientific Council

Research Abstract

My research endeavors seek to bridge advances in novel technologies and therapeutics with current clinical oncology needs. Prior formal intensive training in biomedical research design at the UC Berkeley School of Public Health and at the National Institutes of Health places me in a unique position to translate advances in the lab to the bedside. Moreover, I have broadened my skill set in clinical investigation by completing the Scholars in Clinical Science Program, a two year structured training curriculum that led to a Master of Medical Sciences from Harvard Medical School. I also completed a clinical fellowship in Oncology through the Dana-Farber / Partners Cancer Care Program. This breadth of clinical training exposed me to the day to day quandaries across the spectrum of solid and hematological tumors. Previously, I was involved with nanotechnology research at the National Cancer Institute where I truly first appreciated the meaning of interdisciplinary. I continue the spirit of this approach as Director of the Cancer Program within the MGH Center for Systems Biology. I am now poised to ask further challenging clinical questions in need of innovative solutions. My objectives are to refine and translate novel molecular imaging and nanosensing tactics into solid tumors. My efforts have led to inroads into point-of-care diagnostic solutions for resource-constrained regions globally. My daily research interactions involve an amalgam of chemists, material scientists, engineers, and clinicians as we continue to strive for interdisciplinary, innovative solutions to tackle biological problems plaguing cancer researchers.

Publications from Harvard Catalyst Profiles

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  • Konstantinopoulos PA, Gockley AA, Xiong N, Krasner C, Horowitz N, Campos S, Wright AA, Liu JF, Shea M, Yeku O, Castro C, Polak M, Lee EK, Sawyer H, Bowes B, Moroney J, Cheng SC, Tayob N, Bouberhan S, Spriggs D, Penson RT, Fleming GF, Nucci MR, Matulonis UA. Evaluation of Treatment With Talazoparib and Avelumab in Patients With Recurrent Mismatch Repair Proficient Endometrial Cancer. JAMA Oncol 2022. PubMed
  • Chin LK, Li H, Choi JH, Iwamoto Y, Oh J, Min J, Beak SK, Yoo D, Castro CM, Lee D, Im H. Hydrogel Stamping for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues. 2022; 14:27613-27622. PubMed
  • Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H. Computational Optics for Point-of-Care Breast Cancer Profiling. Methods Mol Biol 2022; 2393:153-162. PubMed
  • Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H. An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng 2021; 5:678-689. PubMed
  • Yang Z, Francisco J, Reese AS, Spriggs DR, Im H, Castro CM. Addressing cervical cancer screening disparities through advances in artificial intelligence and nanotechnologies for cellular profiling. Biophys Rev 2021; 2:011303. PubMed
  • Min J, Chin LK, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R. CytoPAN-Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med 2020. PubMed
  • O'Malley DM, Matulonis UA, Birrer MJ, Castro CM, Gilbert L, Vergote I, Martin LP, Mantia-Smaldone GM, Martin AG, Bratos R, Penson RT, Malek K, Moore KN. Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol 2020. PubMed
  • Yang KS, Lin HY, Curley C, Welch MW, Wolpin BM, Lee H, Weissleder R, Im H, Castro CM. Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry. Adv Biosyst 2020; 4:e2000203. PubMed
  • Chin LK, Son T, Hong JS, Liu AQ, Skog J, Castro CM, Weissleder R, Lee H, Im H. Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research. ACS Nano 2020; 14:14528-14548. PubMed
  • Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H. Multichannel digital heteronuclear magnetic resonance biosensor. Biosens Bioelectron 2019; 126:240-248. PubMed
  • Pathania D, Landeros C, Rohrer L, D'Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM. Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics 2019; 9:8438-8447. PubMed
  • Kim SJ, Wang C, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K. Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep 2018; 8:17003. PubMed
  • Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel JM, Castro CM, Weissleder R, Lee H. Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings. ACS Nano 2018; 12:9081-9090. PubMed
  • Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble B, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R. Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning. Nat Biomed Eng 2018; 2:666-674. PubMed
  • Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H. Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis. ACS Nano 2018. PubMed
  • Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H. New Technologies for Analysis of Extracellular Vesicles. Chem. Rev. 2018; 118:1917-1950. PubMed
  • Park J, Im H, Hong S, Castro CM, Weissleder R, Lee H. Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System. ACS Photonics 2018; 5:487-494. PubMed
  • Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano 2017; 11:11041-11046. PubMed
  • Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H. Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip 2017; 17:4000-4007. PubMed
  • Oza AM, Tinker AV, Oaknin A, Shapira-Frommer R, McNeish IA, Swisher EM, Ray-Coquard I, Bell-McGuinn K, Coleman RL, O'Malley DM, Leary A, Chen LM, Provencher D, Ma L, Brenton JD, Konecny GE, Castro CM, Giordano H, Maloney L, Goble S, Lin KK, Sun J, Raponi M, Rolfe L, Kristeleit RS. Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. Gynecol Oncol 2017. PubMed
  • Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H. Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano 2017. PubMed
  • Im H, Lee K, Weissleder R, Lee H, Castro CM. Novel nanosensing technologies for exosome detection and profiling. Lab Chip 2017; 17:2892-2898. PubMed
  • Yang KS, Im H, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R. Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med 2017. PubMed
  • Castro CM. Good to the last "emulsified" drop. Sci Transl Med 2017. PubMed
  • Im H, Yang K, Lee H, Castro CM. Characterization of Extracellular Vesicles by Surface Plasmon Resonance. Methods Mol Biol 2017; 1660:133-141. PubMed
  • Castro CM. Taking cancer drug screening very personally. Sci Transl Med 2016; 8:367ec190. PubMed
  • Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R. A facile coating strategy to functionalize inorganic nanoparticles for biosensing. Bioconjug Chem 2016. PubMed
  • Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H. Digital diffraction detection of protein markers for avian influenza. Lab Chip 2016; 16:1340-5. PubMed
  • Penson RT, Sales E, Sullivan L, Borger DR, Krasner CN, Goodman AK, Del Carmen MG, Growdon WB, Schorge JO, Boruta DM, Castro CM, Dizon DS, Birrer MJ. A SNaPshot of potentially personalized care: Molecular diagnostics in gynecologic cancer. Gynecol Oncol 2016; 141:108-12. PubMed
  • Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H. Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano 2016; 10:1802-9. PubMed
  • Im H, Lee H, Castro CM. Challenges influencing next generation technologies for precision medicine. Expert Rev Precis Med Drug Dev 2016; 1:121-123. PubMed
  • Pathania D, Im H, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM. Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics 2016; 6:1603-10. PubMed
  • Sosulski A, Horn H, Zhang L, Coletti C, Vathipadiekal V, Castro CM, Birrer MJ, Nagano O, Saya H, Lage K, Donahoe PK, Pépin D. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis. PLoS ONE 2016; 11:e0156595. PubMed
  • Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK. AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A 2015; 112:E4418-27. PubMed
  • Im H, Shao H, Weissleder R, Castro CM, Lee H. Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn 2015; 15:725-33. PubMed
  • Castro CM, Im H, Le C, Lee H, Weissleder R, Birrer MJ. Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies. Cancer Metastasis Rev 2015; 34:75-82. PubMed
  • Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R. On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics 2015; 5:796-804. PubMed
  • Im H, Shao H, Park YI, Peterson VM, Castro CM, Weissleder R, Lee H. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol 2014. PubMed
  • Ghazani AA, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R. Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. 2014; 10:661-8. PubMed
  • Ullal AV, Peterson V, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R. Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci Transl Med 2014; 6:219ra9. PubMed
  • Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H. Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip 2014; 14:14-23. PubMed
  • Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R. Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A 2013; 110:E4978-86. PubMed
  • Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM. Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system. 2013. PubMed
  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia 2013; 15:684-93. PubMed
  • Peterson VM, Castro CM, Lee H, Weissleder R. Orthogonal amplification of nanoparticles for improved diagnostic sensing. ACS Nano 2012. PubMed
  • Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med 2011; 3:71ra16. PubMed
  • Perez DL, Diamond EL, Castro CM, Diaz A, Buonanno F, Nogueira RG, Sheth K. Factor XIII deficiency related recurrent spontaneous intracerebral hemorrhage: a case and literature review. Clin Neurol Neurosurg 2011; 113:142-5. PubMed
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