Photo of Nathan McDannold,  PhD

Nathan McDannold, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 278-0605
Fax: (617) 525-7450


njm@bwh.harvard.edu

Nathan McDannold, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Associate Professor, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory investigates therapeutic uses of ultrasound. Ultrasound, which can be focused deep into the body can be used for a wide range of therapies. Most of my work is centered on using it as a noninvasive tool for ablating tumors or for temporarily modifying vascular barriers to enhance the delivery of drugs. We are particularly interested in the brain, and have been working for years on using focused ultrasound and microbubbles to disrupt the blood-brain barrier. In addition to these basic works, I also have a strong interest in developing imaging methods to guide and monitor focused ultrasound therapies and am closely involved with tumor ablation clinical trials at BWH.

Publications from Harvard Catalyst Profiles

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  • White PJ, Zhang YZ, Power C, Vykhodtseva N, McDannold N. Observed Effects of Whole-Brain Radiation Therapy on Focused Ultrasound Blood-Brain Barrier Disruption. Ultrasound Med Biol 2020; 46:1998-2006. PubMed
  • McDannold N, White PJ, Cosgrove GR. Using phase data from MR temperature imaging to visualize anatomy during MRIguided focused ultrasound neurosurgery. IEEE Trans Med Imaging 2020. PubMed
  • McDannold N, Zhang Y, Supko JG, Power C, Sun T, Vykhodtseva N, Golby AJ, Reardon DA. Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system. Sci Rep 2020; 10:8766. PubMed
  • Todd N, Angolano C, Ferran C, Devor A, Borsook D, McDannold N. Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood-brain barrier. J Control Release 2020; 324:450-459. PubMed
  • Bunevicius A, McDannold NJ, Golby AJ. Focused Ultrasound Strategies for Brain Tumor Therapy. Oper Neurosurg (Hagerstown) 2019. PubMed
  • Todd N, Zhang Y, Livingstone M, Borsook D, McDannold N. The neurovascular response is attenuated by focused ultrasound-mediated disruption of the blood-brain barrier. Neuroimage 2019; 201:116010. PubMed
  • Aryal M, Papademetriou I, Zhang YZ, Power C, McDannold N, Porter T. MRI Monitoring and Quantification of Ultrasound-Mediated Delivery of Liposomes Dually Labeled with Gadolinium and Fluorophore through the Blood-Brain Barrier. Ultrasound Med Biol 2019; 45:1733-1742. PubMed
  • Brinker ST, Preiswerk F, McDannold NJ, Parker KL, Mariano TY. Virtual Brain Projection for Evaluating Trans-skull Beam Behavior of Transcranial Ultrasound Devices. Ultrasound Med Biol 2019; 45:1850-1856. PubMed
  • McDannold N, Zhang Y, Supko JG, Power C, Sun T, Peng C, Vykhodtseva N, Golby AJ, Reardon DA. Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model. Theranostics 2019; 9:6284-6299. PubMed
  • Crake C, Papademetriou IT, Zhang Y, Vykhodtseva N, McDannold NJ, Porter TM. Simultaneous Passive Acoustic Mapping and Magnetic Resonance Thermometry for Monitoring of Cavitation-Enhanced Tumor Ablation in Rabbits Using Focused Ultrasound and Phase-Shift Nanoemulsions. Ultrasound Med Biol 2018. PubMed
  • Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proc Natl Acad Sci U S A 2018; 115:E8717-E8726. PubMed
  • Sun T, Zhang Y, Power C, Alexander PM, Sutton JT, Aryal M, Vykhodtseva N, Miller EL, McDannold NJ. Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model. Proc Natl Acad Sci U S A 2017; 114:E10281-E10290. PubMed
  • McDannold N, Livingstone M, Top CB, Sutton J, Todd N, Vykhodtseva N. Preclinical evaluation of a low-frequency transcranial MRI-guided focused ultrasound system in a primate model. Phys Med Biol 2016; 61:7664-7687. PubMed
  • Park J, Aryal M, Vykhodtseva N, Zhang YZ, McDannold N. Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption. J Control Release 2016. PubMed
  • Kobus T, Zervantonakis IK, Zhang Y, McDannold NJ. Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption. J Control Release 2016; 238:281-8. PubMed
  • Kobus T, Vykhodtseva N, Pilatou M, Zhang Y, McDannold N. Safety Validation of Repeated Blood-Brain Barrier Disruption Using Focused Ultrasound. Ultrasound Med Biol 2015. PubMed
  • Arvanitis CD, Vykhodtseva N, Jolesz F, Livingstone M, McDannold N. Cavitation-enhanced nonthermal ablation in deep brain targets: feasibility in a large animal model. J Neurosurg 2015. PubMed
  • Aryal M, Vykhodtseva N, Zhang YZ, McDannold N. Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study. J Control Release 2015; 204:60-9. PubMed
  • Aryal M, Park J, Vykhodtseva N, Zhang YZ, McDannold N. Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: evaluation during tumor progression in a rat glioma model. Phys Med Biol 2015; 60:2511-27. PubMed
  • McDannold N, Zhang Y, Power C, Arvanitis CD, Vykhodtseva N, Livingstone M. Targeted, noninvasive blockade of cortical neuronal activity. Sci Rep 2015; 5:16253. PubMed
  • Ta T, Bartolak-Suki E, Park EJ, Karrobi K, McDannold NJ, Porter TM. Localized delivery of doxorubicin in vivo from polymer-modified thermosensitive liposomes with MR-guided focused ultrasound-mediated heating. J Control Release 2014; 194C:71-81. PubMed
  • Kopechek JA, Park EJ, Zhang YZ, Vykhodtseva NI, McDannold NJ, Porter TM. Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumors in vivo using phase shift nanoemulsions. Phys Med Biol 2014; 59:3465-81. PubMed
  • Aryal M, Arvanitis CD, Alexander PM, McDannold N. Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system. Adv Drug Deliv Rev 2014. PubMed
  • Jolesz FA, McDannold NJ. Magnetic resonance-guided focused ultrasound: a new technology for clinical neurosciences. Neurol Clin 2014; 32:253-69. PubMed
  • Arvanitis CD, Livingstone MS, McDannold N. Combined ultrasound and MR imaging to guide focused ultrasound therapies in the brain. Phys Med Biol 2013; 58:4749-61. PubMed
  • Aryal M, Vykhodtseva N, Zhang YZ, Park J, McDannold N. Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and blood-brain barriers improve outcomes in a rat glioma model. J Control Release 2013. PubMed
  • Kopechek JA, Park E, Mei CS, McDannold NJ, Porter TM. Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo. J Healthc Eng 2013; 4:109-26. PubMed
  • Park EJ, Zhang YZ, Vykhodtseva N, McDannold N. Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model. J Control Release 2012; 163:277-84. PubMed
  • Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K. Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol 2012; 38:1716-25. PubMed
  • Park J, Zhang Y, Vykhodtseva N, Jolesz FA, McDannold NJ. The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound. J Control Release 2012; 162:134-42. PubMed
  • McDannold N, Arvanitis CD, Vykhodtseva N, Livingstone MS. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res 2012; 72:3652-63. PubMed
  • McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010; 66:323-32; discussion 332. PubMed
  • McDannold N, Vykhodtseva N, Hynynen K. Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol 2008; 34:834-40. PubMed
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