Research Training
The second and third years are optional but strongly encouraged. These years are devoted to laboratory-based, translational, or clinical research. During the autumn of the first year of fellowship, trainees begin exploring options for investigative efforts around their individual interests. Each trainee selects a research mentor who is responsible for specific projects and the educational development of the trainee. Research mentors may be selected from any DF/HCC affiliated institution including MGH, BWH, DFCI, Boston Children’s Hospital, Massachusetts Institute of Technology, Broad Institute of MIT and Harvard, and Harvard Medical School.
Research fellows are supported by intramural funding sources, but are also encouraged as part of the training process to apply for extramural sources of funding. Those interested in a basic or translational science project may apply for a two-year K12 training grant or a T32 cancer neuroscience training grant.
DFCI/BWH and MGH staff members are also very active in brain tumor clinical trial research and are recognized leaders within the field. We participate in all the major consortia for brain tumor clinical trials (including, Alliance, NRG, and ETCTN). We are also a member of the Glioblastoma Therapeutics Network (GTN) through an NIH U19 cooperative agreement. Supervised by faculty and research staff, trainees will care for patients enrolled on clinical trials during their fellowship. Research fellows will also have the opportunity to write and develop new protocols for review by the Institutional Review Board.
Below are examples of research projects by current and recent trainees:
Fellow | Project | Advisor |
Brian Andersen | Characterization and Inhibition of Aryl Hydrocarbon Receptor Signaling in Glioblastoma-Associated Macrophages | Francisco Quintana |
L. Nicolas Gonzalez Castro | Concurrent Epigenomic and Genomic Characterization of IDH-mutant Gliomas at Single Cell Resolution | Mario Suva & Tracy Batchelor |
Mary Jane Lim-Fat | Correlation of Tumor Genomics with Adverse Clinical Outcomes in Glioblastoma | Patrick Wen |
Martha Neagu | Elucidating and Overcoming Immune Evasion by Glioblastoma | Arlene Sharpe |
Nancy Wang | Effects of Wnt inhibition on glioblastoma vasculature | Rakesh Jain |
Ina Ly | Characterization of cellular architecture and microenvironment of IDH1-mutant and IDH1-wild-type gliomas with ultra-high gradient diffusion MRI on the Human Connectome MRI scanner | Elizabeth Gerstner |
Julie Miller | metabolism in IDH mutant glioma | |
David Gritsch | Identification of Novel Biomarkers of Immunotherapy Response in Patients with Brain Metastases | |
Daniel Chiu | A Psychoeducational Intervention for Patients with IDH-mutant Gliomas | Deborah Forst, Jennifer Temel, Michael Parsons |
Thomas Nelson | Electrical Aberrations in the Tumor Microenvironment: Responsive Neurostimulation in the Management of Medically Refractory Epilepsy in Patients with Primary Brain Tumors | Mark Richardson; Scott Plotkin; Humsa Venkatesh; and Brian Nahed |
Annie Hsieh | Identifying Gene Targets that Contribute to Glutamate Release in Gliomas | Bernardo Sabatini and Marcia Haigis |
Tamar Berger | Leveraging Genomic Truncal Alterations in GBM | Rameen Beroukhim and William Kaelin |