UMB & DF/HCC Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) (U54) Pilot & Full Projects

April 16, 2019

The UMass Boston – DF/HCC Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) has released a new Request for Applications! Click here for the full RFA and important dates can be found below:

Deadline for Letter of Intent (Required): May 1, 2019 by 11:59 PM EST
Deadline for Application Submission: June 17, 2019 by 11:59 PM EST
Anticipated Award Date: September 15, 2019

The purpose of this joint grant between UMass Boston and DF/HCC is to foster and support intensive collaborations among investigators at UMass Boston (an institution that serves communities with cancer health disparities) and DF/HCC (an NCI-designated Comprehensive Cancer Center). The NCI Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54) Grant aims to develop stronger national cancer programs to understand the reasons behind the significant cancer disparities and related impacts on underserved communities and socio-economically disadvantaged populations. More specifically, the goal of the UMass Boston-DF/HCC Partnership is to improve cancer-related research, training, and outreach opportunities for under-represented minority (URM) students, fellows, and early stage investigators; and to develop information and resources toward closing the cancer health disparities gap. For more information about the Partnership please visit


A. Pilot Projects (up to $75,000 in direct costs per year for two
B. Full Projects (up to $150,000 in direct costs per year for two years)


All proposed research projects must illustrate collaboration between UMass Boston and DF/HCC researchers and must focus on an aspect of cancer or cancer disparities. Additionally, all research projects must have high potential for leading to external funding through the NIH K-series, R03, R21, R01 mechanisms or through foundation support; and should provide training opportunities for under- represented minority (URM) students and/or fellows. Interested faculty who do not have a DF/HCC or UMass Boston collaborator may request assistance from the Partnership at

Prior to receiving funding from this mechanism, PIs involved must either be current members of the DF/HCC or must submit an application for DF/HCC membership. Faculty at DF/HCC institutions and at UMass Boston are eligible to become DF/HCC members. To apply for membership in the DF/HCC please visit PIs must be appointed as faculty at their respective institutions; post-doctoral fellows are not permitted to serve as PIs on proposals.

Investigators may not a) submit a pilot project application if they have received Partnership pilot project funding within the last two years or b) submit more than one application.

We strongly encourage applications that:

  • Create inter-programmatic interactions between members in clinical- and discipline-based research programs

  • Evaluate biological risk factors that potentially contribute to cancer disparities

  • Include biospecimen procurement for such studies

  • Combine basic and population science methodologies

  • Utilize the U54 cores (see below)

      • Focus on cancer outreach and include hypothesis-driven research that may lead to increased use of and access to beneficial care such as primary preventative measures and/or recruitment and retention of underserved and socio-economically disadvantaged populations into clinical trials for cancer prevention, early detection or treatment

NOTE: NCI is particularly interested in developing educational, outreach and research projects leading to increased biospecimen collection from underserved populations, a critical endeavor to potentially elucidate the biological and genetic factors associated with cancer health disparities.

Submission of a LOI is required. LOIs are limited to two pages in length, should be numbered (if needed) and in PDF format. The LOI should include the following information:

1) A description of the proposed research
2) Specific aims
3) A brief paragraph on the scientific significance and how it relates to the goals of the NCI (CPACHE) and UMass Boston – DF/HCC Partnership
4) 2-3 bullet points on how the outcomes of the proposed work will position the project well for funding as a future Full Project and/or NIH (e.g. R01/R15/R21-level funding) mechanism
5) Contact information for DF/HCC and UMass Boston investigators

Should you have any questions, please feel free to contact the Program Manager, Abby Shain, via email at or via phone at 617-287-6622.

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