The mission of the Medicinal Chemistry Core is to collaborate with researchers to advance their understanding of disease and accelerate the development of novel therapeutic agents. We can assist with all aspects of small molecule drug discovery, from the provision of suitable tool compounds to interrogate basic biology to the optimization of promising lead compounds for animal studies. The labs are fully equipped for synthetic organic chemistry on a small to multi-gram scale, with access to the NMR facilities at DFCI and Harvard Medical School.

Services

• Medicinal chemistry consultation
  - Input for grant applications, project screening strategies, HTS analysis
• Identification and provision of tool compounds
• Long-term drug discovery collaborations
  - Optimization of hit compounds into advanced lead molecules with the potential for further development

PUBLICATION ACKNOWLEDGEMENT

If research supported by this core facility results in publication, please acknowledge this support by including the following in your publication(s):
"We thank Dana-Farber/Harvard Cancer Center in Boston, MA, for the use of the Medicinal Chemistry Core Facility, which provided __________ service. Dana-Farber/Harvard Cancer Center is supported in part by an NCI Cancer Center Support Grant # NIH 5 P30 CA06516."